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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 18.79
Human Site: T583 Identified Species: 25.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 T583 T P G A P A L T S M T P T A V
Chimpanzee Pan troglodytes XP_001165585 1017 111787 T583 T P G A P A L T S M T P T A V
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 T704 T P G A P A L T S V T P T A A
Dog Lupus familis XP_543550 1017 111618 T583 T P G A P A L T S V T P T A M
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 S583 P G A P S L T S V I P T A V E
Rat Rattus norvegicus NP_001129232 1015 111665 S583 P G A P S L T S V I P T A V E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S583 T E R S K A T S G T A V V T N
Frog Xenopus laevis Q8QFR2 1013 112021 L583 G T A G V A H L N Q T A V D R
Zebra Danio Brachydanio rerio XP_696478 1010 111223 T583 V P I T I G I T P L D R A K D
Tiger Blowfish Takifugu rubipres O42611 1025 111838 G583 A A I A S S T G L T P S E R P
Fruit Fly Dros. melanogaster O17468 1047 113397 G580 G H L K T Q H G M L A K V T A
Honey Bee Apis mellifera XP_001122939 838 91355 E429 G P I N K Q I E T R T S D G K
Nematode Worm Caenorhab. elegans Q09589 935 103412 D526 V D L E D S S D S D D D D E E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 T555 V T A R A N I T E S L V I Q K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 S583 S V G I K E S S S T D L L I R
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 F431 L E D Q T K S F K H T K I S T
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 G581 S A K R S A T G P V P I V V N
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 86.6 86.6 N.A. 0 0 N.A. N.A. 13.3 13.3 13.3 6.6 0 13.3 6.6 N.A.
P-Site Similarity: 100 100 93.3 100 N.A. 13.3 13.3 N.A. N.A. 26.6 20 26.6 13.3 6.6 26.6 13.3 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 6.6 N.A. 13.3 6.6 6.6
P-Site Similarity: N.A. 13.3 N.A. 26.6 13.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 12 24 30 6 42 0 0 0 0 12 6 18 24 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 6 6 0 6 0 0 6 0 6 18 6 12 6 6 % D
% Glu: 0 12 0 6 0 6 0 6 6 0 0 0 6 6 18 % E
% Phe: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % F
% Gly: 18 12 30 6 0 6 0 18 6 0 0 0 0 6 0 % G
% His: 0 6 0 0 0 0 12 0 0 6 0 0 0 0 0 % H
% Ile: 0 0 18 6 6 0 18 0 0 12 0 6 12 6 0 % I
% Lys: 0 0 6 6 18 6 0 0 6 0 0 12 0 6 12 % K
% Leu: 6 0 12 0 0 12 24 6 6 12 6 6 6 0 0 % L
% Met: 0 0 0 0 0 0 0 0 6 12 0 0 0 0 6 % M
% Asn: 0 0 0 6 0 6 0 0 6 0 0 0 0 0 12 % N
% Pro: 12 36 0 12 24 0 0 0 12 0 24 24 0 0 6 % P
% Gln: 0 0 0 6 0 12 0 0 0 6 0 0 0 6 0 % Q
% Arg: 0 0 6 12 0 0 0 0 0 6 0 6 0 6 12 % R
% Ser: 12 0 0 6 24 12 18 24 36 6 0 12 0 6 0 % S
% Thr: 30 12 0 6 12 0 30 36 6 18 42 12 24 12 6 % T
% Val: 18 6 0 0 6 0 0 0 12 18 0 12 24 18 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _